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Ancor 2.5mg Tablet 10pcs
Ancor contains Bisoprolol Fumarate, a highly selective β1-adrenergic receptor blocker.
- Reduces heart rate and cardiac output, thereby lowering blood pressure.
- Does not negatively affect lipid metabolism, unlike some non-selective β-blockers.
- Ensures consistent plasma concentration with low variability, making it effective for once-daily dosing.
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✅ Description:
Ancor tablet is used to treat:
- Hypertension (high blood pressure).
- Angina (chest pain due to reduced blood flow to the heart).
- Moderate to severe heart failure.
Note: Ancor is not suitable for emergency treatment of hypertensive crises.
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✔️ Pharmacology
Absorption and Distribution:
- Well absorbed (>90%) from the gastrointestinal tract with 88% bioavailability.
- Food intake does not affect absorption.
Metabolism and Elimination:
- Metabolized primarily by CYP3A4 in the liver, with minor involvement of CYP2D6.
- Cleared equally via renal excretion and hepatic metabolism.
- Half-life: 10–12 hours.
✔️ Possible side effects include
- Common: Fatigue, dizziness, headache, nausea, vomiting, diarrhea, constipation, abdominal pain.
- Other: Cold or numb extremities, muscle weakness or cramps, bradycardia, bronchospasm (in asthma or COPD patients).
✔️ Dosage & Administration
- Adults: Start with 5 mg once daily, alone or with a diuretic. Increase to 10–20 mg daily if needed, with 2-week intervals for dose adjustment.
- Children: Safety and effectiveness not established.
- Renal/Hepatic Impairment: Start with 5 mg daily; adjust the dose with caution due to the risk of accumulation.
- Elderly: No dose adjustment is needed unless significant renal or hepatic dysfunction is present.
✔️ Interaction Information
- Class I Antiarrhythmic Drugs (e.g., quinidine, disopyramide, propafenone):
May prolong AV conduction time and increase the negative inotropic effect, leading to further slowing of heart function. - Catecholamine-depleting Drugs (e.g., reserpine, guanethidine):
Can cause excessive sympathetic activity reduction, potentially resulting in severe bradycardia or hypotension. - Clonidine Withdrawal:
May worsen rebound hypertension if β-blockers are not withdrawn several days prior to stopping clonidine. - Digitalis Glycosides:
Concurrent use may increase the risk of bradycardia due to additive effects on slowing heart rate. - NSAIDs (e.g., ibuprofen, naproxen):
Can reduce the antihypertensive effect of β-blockers, possibly reducing treatment efficacy.
✔️ Do not use in patients with:
- Cardiogenic shock.
- Overt heart failure.
- Second- or third-degree A-V block.
- Sinus bradycardia.
- Right ventricular failure due to pulmonary hypertension.
✔️ Precautions & Warnings
- Use with caution in patients with renal or hepatic impairment.
- Patients with a history of severe anaphylactic reactions may be less responsive to epinephrine while on β-blockers.
- Pregnant women should use Ancor only if the benefits outweigh the risks.
✔️ Pregnancy & Lactation
- Pregnancy: Bisoprolol is not teratogenic but may be fetotoxic at high doses. Use only if necessary.
- Lactation: Small amounts may be excreted in human milk; breastfeeding is not recommended during treatment.
✔️ Storage Instructions
- Store in a dry place, away from light and heat.
- Keep out of reach of children.
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